The thesis “Achieving competitive advantage in global markets” contains the historical development and the beginning of globalization, new economies, internationalization and sustainable growth and development of companies. These four notions form the basis of this thesis. New global strategies are the outcome of achieving competitive advantage, therefore states and national companies invest their resources in them because they are faced with their ever more successful and profitable progress. This thesis emphasizes the importance of recognizing and applying the ability to create and accomplish a certain strategic goal of a company. The thesis mentions global competitiveness indexes as the main statistical factors in assessing the competitiveness of countries or companies in the international market. The Global Competitiveness Index is the reason for conducting a significant number of analyses in which macroeconomic indicators affect the institutional development or underdevelopment. The Index of Economic Freedom, the Index of Human Capital Development, Corruption Perceptions Index, World Governance Indicators, business and the European innovation order are one of the most important indicators on the basis of which the competitiveness of particular countries, and later companies, is assessed. The market is becoming global, open to the whole world. Companies must develop products that meet the individual customer’s wishes, if they strive to achieve the increase of profitability and competitiveness in the market. By investing in their employees’ education, conducting research and encouraging innovation, companies are investing in their own future. Relying on Blue Ocean Strategies, which involve investing in their own potential and their own progress, companies avoid confronting and competing with the competition (Red Ocean), thus becoming an innovation for themselves, as well as for new global open markets. Companies are evolving and growing. If we focus on the size profile and the growth profile, direction of growth, the ability and path of growth and the overall organization, we conclude that there are companies which act as local, regional, international or global participants in the industry. Companies therefore often operate as clusters in order to achieve greater advantage, innovation, knowledge and competitiveness in global markets.