The purpose of this diploma thesis is to show on how the Institute of Immunology works and the challenges it faces. Since the Institute of Immunology has existed and has been operating for years, like any institution, it is facing a crisis and a strategy for solving the crisis is being developed on a daily basis. The work is conceptualized in four parts. The first part of the paper refers to the theoretical part and describes the concept of crisis, how it occurs in companies, what types of crisis in business and organization exist and how they are resolved. The second part describes only the activities of the Institute of Immunology, its meaning and purpose, how it operates and works. The detailed financial situation and its impact on health care in the Republic of Croatia are presented. Mention is also made of the crisis facing the institute and the way in which communication itself took place in the crisis The third part of the paper is based on the risk of solving the crisis in the Institute of Immunology, the types of resolution strategies and setting goals that could reduce the risk. By carefully selecting strategic partners, the Institute of Immunology faced the challenges of doing business and chose the traditional way to manage risk. The fourth part of the paper describes how the Institute of Immunology defined the goals of the organization with a new strategic plan, what it was based on, and what rules were applied during the reorganization and resolution of the crisis. A new business organization has been set up with business units that are strategically designed to get the Institute of Immunology out of the business crisis and continue to operate smoothly with certain measures and activities.